Beschreibung (Langtext)

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.
This important volume provides an understanding of the molecular mechanisms involved in melanogenesis and in malignant transformation of melanocytes. By studying the molecular signals involved in these processes, model systems can be developed that trace the molecular mechanisms involved in the malignant transformation of melanocytes to malignant melanoma.